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Volume 3, No. 3, September, 2002
Plasma fibronectin levels in early respiratory distress syndrome
Murat Yurdakök, MD, Sule Yigit, MD, Didem Aliefendioglu, MD
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
Premature infants with respiratory distress syndrome (RDS) have significantly lower plasma fibronectin levels by an enzyme immunoassay method
in the first days of life than those of healthy infants. Therefore, we examined the plasma fibronectin levels in 39 preterm infants who developed RDS or not within six hours after birth to see whether its reduction is a primary or secondary event. Mean plasma fibronectin levels were found to be similar in infants who developed RDS compared to the healthy control group. The findings of this study suggest that reduced plasma fibronectin levels in developed RDS may be secondary to the lung injury.INTERLEUKIN-1, INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR IN EARLY NEONATAL RESPIRATORY DISTRESS SYNDROME
Murat Yurdakök MD, Didem Aliefendioglu MD, Necla Tülek MD, Sule Yigit MD
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
SUMMARYPlasma concentrations of tumor necrosis factor alpha (TNF?), interleukin-1 ? (IL-1?) and interleukin-6 (IL-6) were studied in 31 preterm infants within six hours after birth to determine whether respiratory distress syndrome alters expression of these proinflammatory cytokines which modulate lung inflammation. The mean plasma TNF?, IL-1? and IL-6 levels were found to be similar in infants who developed RDS (n: 14) and in the controls (n: 17). According to the findings of this study; there is no abnormality in plasma TNF?, IL-1? and IL-6 levels in developing respiratory distress syndrome.
Tumor necrosis factor alpha (TNF?), interleukin-1 ? (IL-1?) and interleukin-6 (IL-6) are markedly elevated in tracheobronchial aspirate fluids from neonates with bronchopulmonary dysplasia (1). However, it is not known whether these levels are already increased before the development of respiratory distress syndrome (RDS) or increased due to the lung damage in developed RDS. Therefore, we studied plasma concentrations of TNF?, IL-1? and IL-6 in preterm infants in the first few hours of life to determine whether RDS alters expression of these proinflamatory cytokines which modulate lung inflammation.
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